mesna

{
  "id": "MLC-T-ONC-005284",
  "term": "mesna",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to prevent hemorrhagic cystitis (bleeding in the bladder) caused by the anticancer drug ifosfamide. Mesna helps protect healthy tissue from some of the side effects caused by certain anticancer drugs. It is a type of chemoprotective agent. Also called Mesnex.",
    "A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion."
  ],
  "abbreviation": "MSA",
  "synonyms": [
    "Mesnex",
    "mercaptoethane sulfonate",
    "Mesnum"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mesna/"
}