Metoprine

{
  "id": "MLC-T-ONC-015143",
  "term": "Metoprine",
  "field": "Oncology and biomedicine",
  "definition": "A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capable of crossing the blood-brain barrier.",
  "abbreviation": "DDMP",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/metoprine/"
}