microRNA-10b antagomir-iron oxide/dextran-based nanoparticle TTX-MC138

{
  "id": "MLC-T-ONC-015172",
  "term": "microRNA-10b antagomir-iron oxide/dextran-based nanoparticle TTX-MC138",
  "field": "Oncology and biomedicine",
  "definition": "A nanoparticle-based formulation containing an antagomir and oligonucleotide targeting microRNA-10b (miR-10b) encapsulated within a nanoparticle consisting of an iron oxide core that is coated with dextran, with potential antineoplastic activity. Upon administration of microRNA-10b antagomir-iron oxide/dextran-based nanoparticle TTX-MC138, the anti-miR-10b moiety targets and binds to miR-10b inside tumor cells. This inhibits miR-10b and kills miR-10b-overexpressing tumor cells. This may inhibit tumor progression and metastasis. miR-10b, a non-coding RNA that is highly expressed in a variety of metastatic tumor cells, plays a key role in tumor cell migration, invasion and metastasis. The dextran coated iron oxide nanoparticles allow for an increased half-life, decreased clearance and increased tumor cell uptake.",
  "synonyms": [
    "anti-miR-10b nanoparticle TTX-MC138",
    "microRNA-10b inhibitor TTX-MC138",
    "microRNA-10b-targeted nanoparticle-based formulation TTX-MC138",
    "miR-10b antagomir-containing iron oxide-based nanoparticle TTX-MC138",
    "miR-10b inhibitor TTX-MC138"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/microrna-10b-antagomir-iron-oxide-dextran-based-nanoparticle-ttx-mc138/"
}