mitoguazone

{
  "id": "MLC-T-ONC-015207",
  "term": "mitoguazone",
  "field": "Oncology and biomedicine",
  "definition": "A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation.",
  "abbreviation": "MGBG",
  "synonyms": [
    "methylglyoxal bisguanylhydrazone",
    "mitoguazone dihydrochloride",
    "pyruvaldehyde bis(amidinohydrazone)"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mitoguazone/"
}