Modakafusp alfa

{
  "id": "MLC-T-ONC-015221",
  "term": "Modakafusp alfa",
  "field": "Oncology and biomedicine",
  "definition": "A proprietary preparation composed of an immunoglobulin G4 (IgG4) directed against the cell surface glycoprotein CD-38 (CD38) that is fused to an attenuated form of human interferon alpha (IFN alpha; IFNa), with potential immunomodulating and antineoplastic activities. Upon administration, modakafusp alfa specifically targets and binds to CD38 on CD38-positive tumor cells. In turn, the IFNa moiety binds to cell-surface IFN receptors, and activates IFN-mediated signal transduction pathways, which results in the transcription and translation of genes whose products may cause antiproliferative effects in CD38-positive tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis.",
  "synonyms": [
    "CD38-targeted IgG4 fused with attenuated IFNa",
    "anti-CD38-targeted IgG4-attenuated interferon alpha TAK-573",
    "anti-CD38-targeted IgG4-attenuated IFNa TAK-573"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/modakafusp-alfa/"
}