Nanoparticle encapsulated AChR epitopes CNP-106

{
  "id": "MLC-T-ONC-015422",
  "term": "Nanoparticle encapsulated AChR epitopes CNP-106",
  "field": "Oncology and biomedicine",
  "definition": "A nanoparticle-based formulation consisting of an antigenic acetylcholine receptor (AChR) peptide pool dispersed within a negatively charged polymer matrix of poly(dl-lactide-co-glycolide) (PLGA) particles, with potential immunomodulatory activity. Upon administration, nanoparticle encapsulated AChR epitopes CNP-106 binds to inflammatory cells and delivers multiple AChR epitopes, which initiates tolerogenic immune reprogramming. This may induce and promote antigen-specific tolerance against AChR, which may prevent neuromuscular junction damage and dysfunction that results from autoimmunity targeting AChR.",
  "synonyms": [
    "CNPs encapsulating AChR peptides CNP-106"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nanoparticle-encapsulated-achr-epitopes-cnp-106/"
}