neoantigen srRNA vaccine JCXH-212

{
  "id": "MLC-T-ONC-015473",
  "term": "neoantigen srRNA vaccine JCXH-212",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of self-replicating RNA (srRNA) encoding a patient's tumor-specific neoantigens, with potential immunomodulatory and antineoplastic activities. Upon administration of neoantigen srRNA vaccine JCXH-212, the srRNA is taken up by and translated into the neoantigens in the patient's antigen-presenting cells (APCs), primarily dendritic cells (DCs), and presented by major histocompatibility complex (MHC) molecules on the surface of the APCs. This may activate tumor antigen-specific T-cells to kill cancer cells expressing these neoantigens.",
  "synonyms": [
    "vaccine JCXH-212"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/neoantigen-srrna-vaccine-jcxh-212/"
}