NLRP3 agonist BMS-986299

{
  "id": "MLC-T-ONC-015527",
  "term": "NLRP3 agonist BMS-986299",
  "field": "Oncology and biomedicine",
  "definition": "A nucleotide-binding domain and leucine-rich repeat (NLR) family pyrin domain containing 3 (NLRP3; NACHT, LRR and PYD Containing Protein 3; NALP3) agonist with potential immunomodulatory and antineoplastic activities. Upon administration, NLRP3 agonist BMS-986299 binds to and activates NLRP3, potentially promoting NLRP3 inflammasome-mediated secretion of interleukin-8 (IL-8), which may induce tumoricidal activity of natural killer (NK) cells against tumor cells. NLRP3, a sensor component of the NLRP3 inflammasome plays a significant role in immunity and inflammation, and may protect against tumorigenesis in some cancers.",
  "synonyms": [
    "NLR family pyrin-domain-containing 3 agonist BMS-986299"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nlrp3-agonist-bms-986299/"
}