omacetaxine mepesuccinate

{
  "id": "MLC-T-ONC-006057",
  "term": "omacetaxine mepesuccinate",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat adults with certain types of chronic myelogenous leukemia that cannot be treated with tyrosine kinase inhibitors (a type of anticancer drug) or that have not gotten better after treatment with at least two tyrosine kinase inhibitors. It is also being studied in the treatment of other types of cancer. Omacetaxine mepesuccinate blocks certain proteins involved in cell growth and may kill cancer cells. It is a type of plant alkaloid and a type of protein synthesis inhibitor. Also called homoharringtonine and Synribo.",
    "A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types."
  ],
  "abbreviation": "HHT",
  "synonyms": [
    "homoharringtonine",
    "Synribo"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/omacetaxine-mepesuccinate/"
}