pexidartinib hydrochloride

{
  "id": "MLC-T-ONC-006564",
  "term": "pexidartinib hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat adults with tenosynovial giant cell tumor (a rare, usually benign tumor that affects the joints). It is used in patients who have a severe form of the disease that is not likely to get better with surgery. It is also being studied in the treatment of some types of cancer and other conditions. Pexidartinib hydrochloride blocks certain proteins, which may help keep tumor cells from growing and spreading. It is a type of tyrosine kinase inhibitor. Also called Turalio.",
    "The hydrochloride salt form of pexidartinib, a small-molecule receptor tyrosine kinase (RTK) inhibitor of proto-oncogene receptor tyrosine kinase (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), with antineoplastic activity. Upon oral administration, pexidartinib targets, binds to and inhibits phosphorylation of KIT, CSF1R and FLT3 harboring an internal tandem duplication (ITD) mutation. This results in the inhibition of tumor cell proliferation. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis."
  ],
  "synonyms": [
    "Turalio",
    "PLX3397 HCl",
    "PLX3397 hydrochloride"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pexidartinib-hydrochloride/"
}