PI3K inhibitor BGT226

{
  "id": "MLC-T-ONC-016027",
  "term": "PI3K inhibitor BGT226",
  "field": "Oncology and biomedicine",
  "definition": "A phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BGT226 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins.",
  "synonyms": [
    "phospatidylinositol 3'-kinase inhibitor BGT226"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pi3k-inhibitor-bgt226/"
}