Plerixafor

{
  "id": "MLC-T-ONC-006744",
  "term": "Plerixafor",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used with granulocyte colony-stimulating factor before an autologous stem cell transplant in patients with non-Hodgkin lymphoma or multiple myeloma. It is also being studied in the treatment of other types of cancer. Plerixafor helps move stem cells from the bone marrow to the blood so they can be collected, stored, and then given back to the patient. Plerixafor is a type of hematopoietic stem cell mobilizer. Also called AMD 3100 and Mozobil.",
    "A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation."
  ],
  "synonyms": [
    "AMD 3100",
    "Mozobil"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/plerixafor/"
}