CXCR2 agonist MGTA-145

{
  "id": "MLC-T-ONC-012844",
  "term": "CXCR2 agonist MGTA-145",
  "field": "Oncology and biomedicine",
  "definition": "An agonist of CXC chemokine receptor type 2 (CXCR2), with potential hematopoietic stem cell (HSC) mobilization activity. Upon administration, CXCR2 agonist MGTA-145 binds to and activates CXCR2. This releases matrix metalloproteinase-9 (MMP-9), resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. The HSCs can be collected for autologous and allogeneic stem cell transplantation.",
  "synonyms": [
    "GRO-beta",
    "GROb"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cxcr2-agonist-mgta-145/"
}