plitidepsin

{
  "id": "MLC-T-ONC-016116",
  "term": "plitidepsin",
  "field": "Oncology and biomedicine",
  "definition": "A cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth.",
  "abbreviation": "DDB",
  "synonyms": [
    "aplidine",
    "dehydrodemnin B",
    "dehydrodidemnin B"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/plitidepsin/"
}