Polyethylene glycol recombinant endostatin

{
  "id": "MLC-T-ONC-016157",
  "term": "Polyethylene glycol recombinant endostatin",
  "field": "Oncology and biomedicine",
  "definition": "A formulation containing recombinant endostatin attached to polyethylene glycol (PEG), with potential anti-angiogenic and antineoplastic activities. Endostatin, a 20 kDa C-terminal proteolytic fragment of collagen XVIII, induces microvascular endothelial cell apoptosis and inhibits endothelial proliferation and angiogenesis, which may result in a reduction of tumor cell growth. Modification with PEG extends the circulation half-life of endostatin, improves stability and increases solubility in organic solvents.",
  "synonyms": [
    "M2ES"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/polyethylene-glycol-recombinant-endostatin/"
}