recombinant human endostatin

{
  "id": "MLC-T-ONC-016415",
  "term": "recombinant human endostatin",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant human proteolytic fragment of the C-terminal end of type XVIII collagen. Endostatin induces microvascular endothelial cell apoptosis and inhibits endothelial proliferation and angiogenesis, which may result in a reduction in tumor burden. This agent also may decrease hepatic metastasis by inhibiting proinflammatory cytokines and vascular cell adhesion molecule (VCAM)-dependent cell attachment to the hepatic microvasculature.",
  "synonyms": [
    "endostatin",
    "N-terminal-MGGSHHHHH-endostatin (human recombinant)",
    "recombinant endostatin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/recombinant-human-endostatin/"
}