PR1 leukemia peptide vaccine

{
  "id": "MLC-T-ONC-016201",
  "term": "PR1 leukemia peptide vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine containing PR1, a 9 amino-acid human leukocyte antigen (HLA)-A2 restricted peptide derived from proteinase 3, with potential immunotherapeutic activity. Vaccination with PR1 leukemia peptide vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing proteinase 3, resulting in tumor cell lysis. Often overexpressed in leukemic cells, proteinase 3 is a serine proteinase that activates progelatinase A and is involved in angiogenesis and metastasis.",
  "abbreviation": "PR1 vac",
  "synonyms": [
    "proteinase 3 PR1 peptide",
    "leukemia peptide vaccine, PR1",
    "proteinase 3:PR1 peptide"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pr1-leukemia-peptide-vaccine/"
}