radium Ra 223-dichloride

{
  "id": "MLC-T-ONC-007203",
  "term": "radium Ra 223-dichloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A radioactive drug used to treat prostate cancer that has spread to the bone and is causing symptoms but has not spread to other organs. It is used in patients whose cancer is castration resistant (has not responded to treatments that lower testosterone levels). It is also being studied in the treatment of other types of cancer. Radium Ra 223-dichloride contains a radioactive substance called radium Ra 223. It collects in bone and gives off radiation that may kill cancer cells. Radium Ra 223-dichloride is a type of radiotherapeutic agent. Also called Xofigo.",
    "A radiopharmaceutical composed of the dichloride salt of the alpha-emitting isotope radium Ra 223, with antineoplastic activity. Like calcium, radium targets bone tissue and preferentially accumulates in osteoblastic lesions, such as those seen in areas of bone metastases. Radium Ra 223 forms complexes with hydroxyapatite and becomes incorporated into the bone matrix. The radioisotope Ra 223 kills bone cancer cells through local emission of high energy alpha particles, causing DNA double-strand breaks and tumor regression in the skeleton. The short range effects of alpha emission allows for localized DNA damage with limited toxicity to nearby healthy bone tissue."
  ],
  "synonyms": [
    "Xofigo",
    "radium 223 dichloride",
    "radium-223 dichloride",
    "radium-223 chloride",
    "alpharadin"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/radium-ra-223-dichloride/"
}