Recombinant CD40-ligand

{
  "id": "MLC-T-ONC-016394",
  "term": "Recombinant CD40-ligand",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant therapeutic agent which is chemically identical to or similar to CD40-ligand. CD40-ligand, also known as CD40L/TRAP and CD154, is a type II membrane protein which binds to CD40, a cell surface receptor that belongs to the tumor necrosis factor receptor family; CD40 is expressed on B lymphocytes, monocytes, dendritic cells (DC), hematopoietic progenitors, endothelial cells and epithelial cells. Recombinant CD40-ligand may be used to activate DC ex vivo via CD40 binding; CD40-ligand-activated DC may provide or augment a protective antitumor immunity when administered in dendritic cell cancer vaccines.",
  "abbreviation": "CD40L",
  "synonyms": [
    "CD154 antigen",
    "gp39",
    "T-BAM",
    "T-cell antigen gp39",
    "TNF-related activation protein",
    "TRAP ligand"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/recombinant-cd40-ligand/"
}