recombinant platelet factor 4

{
  "id": "MLC-T-ONC-016454",
  "term": "recombinant platelet factor 4",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant form of the endogenous chemokine platelet factor 4 with potential antiangiogenesis and antineoplastic activities. As a heparin-binding tetramer, recombinant platelet factor 4 inhibits growth factor-stimulated endothelial cell proliferation, migration, and angiogenesis; it has been shown that this agent inhibits fibroblast growth factor 2 (FGF2) angiogenic activity downstream from the FGF2 receptor. Its activity is antagonized by heparin. Recombinant platelet factor 4 may also directly inhibit the proliferation of some tumor cell types.",
  "abbreviation": "rPF4",
  "synonyms": [
    "platelet factor 4",
    "recombinant human platelet factor 4",
    "CXC-chemokine PF-4",
    "CXCL4"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/recombinant-platelet-factor-4/"
}