recombinant vaccinia-multiepitope melanoma peptides-B7.1-B7.2 vaccine

{
  "id": "MLC-T-ONC-016470",
  "term": "recombinant vaccinia-multiepitope melanoma peptides-B7.1-B7.2 vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of an inactivated recombinant vaccinia virus encoding epitope peptides derived from melanoma-related HLA-A2-restricted tumor-associated antigens (TAAs), including Melan-A(27-35), gp100(280-288) and tyrosinase(1-9), and two co-stimulatory B7 proteins, B7.1 (CD80) and B7.2 (CD86). Upon administration, recombinant vaccinia-multiepitope melanoma peptides-B7.1-B7.2 vaccine may stimulate a cytotoxic T-lymphocyte response against melanoma cells that express TAAs which share epitopes with the epitope peptides expressed by the vaccine viral vector, resulting in tumor cell lysis; vaccine viral vector-expressed co-stimulatory proteins B7.1 and B7.2 may enhance the cytotoxic T-lymphocyte immune response to the TAAs.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/recombinant-vaccinia-multiepitope-melanoma-peptides-b7-1-b7-2-vaccine/"
}