RIG-I selective ligand RGT100

{
  "id": "MLC-T-ONC-016540",
  "term": "RIG-I selective ligand RGT100",
  "field": "Oncology and biomedicine",
  "definition": "A synthetic RNA oligonucleotide and agonist of the retinoic acid-inducible gene I protein (RIG-I; DDX58), with potential antineoplastic activity. Upon intratumoral/intralesional administration, the RIG-I selective ligand RGT100 targets and binds to the cytosolic RNA receptor RIG-I. This induces RIG-I-mediated signaling, upregulates interferon (IFN)-alfa (IFN-a) and beta (IFN-b), and induces a potent IFN-mediated innate immune response against the tumor cells. This induces the activation of natural killer (NK) cells and cytotoxic T lymphocytes (CTL) and induces apoptosis in cancer cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/rig-i-selective-ligand-rgt100/"
}