tositumomab

{
  "id": "MLC-T-ONC-008770",
  "term": "tositumomab",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used together with another drug to treat certain types of B-cell non-Hodgkin lymphoma. It is also being studied in the treatment of other types of cancer. Tositumomab binds to a protein called CD20, which is found on the surface of B cells, and may kill cancer cells. It is a type of monoclonal antibody.",
    "A murine IgG2 monoclonal antibody directed against the CD20 antigen, found on the surface of B cells. Tositumomab binds to the CD20 surface membrane antigen, resulting in apoptosis, and may stimulate antitumoral cell-mediated and/or antibody-dependent cytotoxicity."
  ],
  "abbreviation": "MOAB anti-B1",
  "synonyms": [
    "anti-B1 monoclonal antibody",
    "anti-CD20 antibody",
    "anti-B1"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tositumomab/"
}