Trientine hydrochloride

{
  "id": "MLC-T-ONC-017321",
  "term": "Trientine hydrochloride",
  "field": "Oncology and biomedicine",
  "definition": "The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8).",
  "abbreviation": "TETA",
  "synonyms": [
    "triethylenetetramine dihydrochloride"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/trientine-hydrochloride/"
}