Universal donor expanded TGF-beta-imprinted NK cells

{
  "id": "MLC-T-ONC-017409",
  "term": "Universal donor expanded TGF-beta-imprinted NK cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of ex vivo expanded, universal donor, transforming growth factor-beta (TGF-beta; TGF-b) imprinted natural killer (NK) cells, with potential cytolytic and antineoplastic activities. Upon administration, the universal donor expanded TGF-beta-imprinted NK cells may directly lyse cancer cells. These cells also secrete pro-inflammatory cytokines and further stimulate a systemic immune response against cancer cells. TGF-beta imprinting during NK cell activation and expansion decreases NK cell sensitivity to TGF-beta suppression and promotes NK cell cytokine hypersecretion, specifically of interferon-gamma (IFNg) and tumor necrosis factor-alpha (TNFa), and enhances NK cytotoxicity. TGF-beta is a potent immunosuppressive cytokine that inhibits the anti-tumor responses of NK cells and T cells.",
  "synonyms": [
    "allogeneic TGFBi expanded NK cells",
    "universal donor TGF-beta imprinted expanded NK cells",
    "UD TGF-betai NK Cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/universal-donor-expanded-tgf-beta-imprinted-nk-cells/"
}