anti-TGF-beta monoclonal antibody SAR-439459

{
  "id": "MLC-T-ONC-011110",
  "term": "anti-TGF-beta monoclonal antibody SAR-439459",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody (mAb) directed against human transforming growth factor beta (TGF-beta; TGFb), with potential antineoplastic activity. Upon administration, anti-TGF-beta monoclonal antibody SAR-439459 specifically targets and binds to TGF-beta, thereby preventing the activation of TGF-beta-mediated signaling pathways. This may inhibit the proliferation of tumor cells in which TGF-beta is overactivated. TGF-beta, a pro-inflammatory mediator that is mutated and/or overexpressed in a variety of cancer cell types, is involved in cancer cell proliferation and migration, and in tumor progression.",
  "synonyms": [
    "anti-transforming growth factor-beta mAb SAR439459",
    "anti-TGFb SAR-439459"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-tgf-beta-monoclonal-antibody-sar-439459/"
}