anti-TGF-beta 1/Anti-COX-2 siRNAs STP707

{
  "id": "MLC-T-ONC-011109",
  "term": "anti-TGF-beta 1/Anti-COX-2 siRNAs STP707",
  "field": "Oncology and biomedicine",
  "definition": "A polypeptide nanoparticle (PNP)-based therapeutic comprised of two small interfering RNA (siRNA) oligonucleotides directed against transforming growth factor-beta 1 (TGF-beta 1) and cyclo-oxygenase-2 (COX-2), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, anti-TGF-beta 1/anti-COX-2 siRNAs STP707 binds to both TGF-beta 1 and COX-2 messenger RNAs (mRNAs), preventing the translation and expression of TGF-beta 1 and COX-2 proteins. This inhibits TGF-beta 1-mediated signaling and abrogates TGF-beta 1-mediated immunosuppression, which may enhance anti-tumor immunity in the tumor microenvironment (TME) and promote a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells leading to tumor cell death. The inhibition of COX-2 prevents COX-2-mediated signaling, which may result in apoptosis and a reduction in tumor cell proliferation, tumor angiogenesis and metastasis.",
  "synonyms": [
    "anti-TGF-beta 1/COX-2 siRNAs STP707",
    "anti-TGF-beta 1/anti-COX-2 siRNA oligonucleotides STP707"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-tgf-beta-1-anti-cox-2-sirnas-stp707/"
}