Zosuquidar trihydrochloride

{
  "id": "MLC-T-ONC-009499",
  "term": "Zosuquidar trihydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of cancer. Zosuquidar trihydrochloride may help kill cancer cells that are resistant to anticancer drugs. Also called LY335979.",
    "A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents."
  ],
  "synonyms": [
    "LY335979"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/zosuquidar-trihydrochloride/"
}