Systems and methods for fluid and component handling

{
  "publication_number": "US10012664B2",
  "country": "US",
  "kind": "B2",
  "title": "Systems and methods for fluid and component handling",
  "abstract": "Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.",
  "claims": [
    "1. A method for transporting a sample processing component in a sample processing device, the method comprising: engaging the sample processing component with at least a first nozzle and a second nozzle of a fluid handling apparatus, the fluid handling apparatus comprising at least a first pipette head and a second pipette head, the first pipette head comprising the first nozzle and the second pipette head comprising the second nozzle, and wherein the sample processing component is at a first location in the device prior to being engaged by the first and second nozzle; and transporting by the fluid handling apparatus the engaged sample processing component to a second location in the device.",
    "2. The method of claim 1, wherein the fluid handling apparatus further comprises a third pipette head, the third pipette head comprising a third nozzle, and wherein the sample processing component is not engaged with the third nozzle when the sample processing component is transported by the fluid handling apparatus.",
    "3. The method of claim 2, wherein the first, second, and third pipette heads are arranged in a configuration, and wherein the first and second pipette heads are separated from each other in the configuration by at least the third pipette head.",
    "4. The method of claim 1, further comprising: disengaging the sample processing component from the first nozzle and the second nozzle at the second location in the device.",
    "5. The method of claim 4, further comprising: after disengaging the sample processing component, engaging a pipette tip with the first nozzle of the fluid handling apparatus; and aspirating a liquid into or dispensing a liquid from the pipette tip.",
    "6. The method of claim 3, wherein the configuration is a row.",
    "7. The method of claim 1, wherein the first pipette head contains a fluid path which terminates at the first pipette nozzle, and the first pipette head contains a plunger which is movable along at least a portion of the fluid path.",
    "8. The method of claim 1, wherein the sample processing component is a cuvette carrier or a strip of vessels.",
    "9. The method of claim 1, wherein the fluid handling apparatus further comprises a component removal mechanism for disengaging the sample processing component from at least one of the pipette nozzles.",
    "10. A method of handling components in a sample processing device comprising a fluid handling apparatus, the method comprising: engaging a pipette tip with a first nozzle of the fluid handling apparatus, the fluid handling apparatus comprising at least the first nozzle and a second nozzle; disengaging the pipette tip from the first nozzle; engaging simultaneously a first pick-up interface of a cuvette with the first nozzle and a second pick-up interface of the cuvette with the second nozzle, wherein the cuvette comprises i) the first pick-up interface and the second pick-up interface, each interface being configured to engage a nozzle of the fluid handling apparatus, and ii) at least a first cavity and a second cavity, each cavity being configured to accept a fluid; transporting the engaged cuvette; and disengaging the cuvette from the first and second nozzle.",
    "11. The method of claim 10, further comprising, after engaging and before disengaging the pipette tip from the first nozzle, aspirating a liquid into or dispensing a liquid from the pipette tip.",
    "12. The method of claim 10, wherein, prior to being engaged, the cuvette is in a first location in the device, and after being disengaged, the cuvette is in a second location in the device.",
    "13. The method of claim 12, wherein the second location is a spectrophotometer.",
    "14. The method of claim 10, wherein, prior to being engaged, the pipette tip is in a cartridge in the sample processing device, the cartridge being insertable into the sample processing device, and after being disengaged, the pipette tip is in the same cartridge.",
    "15. The method of claim 10, wherein the fluid handling apparatus further comprises a third nozzle, and wherein the cuvette is not engaged with the third nozzle when the first pick-up interface of the cuvette is engaged by the first nozzle and the second pick-up interface of the cuvette is engaged by the second nozzle.",
    "16. The method of claim 10, wherein the first pick-up interface is at least a portion of the first cavity of the cuvette.",
    "17. The method of claim 10, wherein the first pick-up interface is separate from both the first cavity and second cavity of the cuvette.",
    "18. The method of claim 10, wherein the first cavity and the second cavity of the cuvette are fluidically linked.",
    "19. The method of claim 10, wherein the first cavity and the second cavity of the cuvette are fluidically isolated."
  ],
  "description_excerpt": "The majority of clinical decisions are based on laboratory and health test data, yet the methods and infrastructure for collecting such data severely limit the quality and utility of the data itself. Almost all errors in laboratory testing are associated with human or pre-analytic processing errors, and the testing process can take days to weeks to complete. Often times by the time a practicing physician gets the data to effectively treat a patient or determine the most appropriate intervention, he or she has generally already been forced to treat a patient empirically or prophylactically as the data was not available at the time of the visit or patient triage. Earlier access to higher quality testing information at the time of patient triage enables earlier interventions and better management of disease progression to improve outcomes and lower the cost of care.\n\nExisting systems and methods for clinical testing suffer major drawbacks from the perspectives of patients, medical care professionals, taxpayers, and insurance companies. Today, consumers can undergo certain specialized tests at clinics or other specialized locations. If a test is to be conducted and the result of which is to be eventually relied on by a doctor, physical samples are transported to a location which performs the test on the samples. For example, these samples may comprise blood from a venous draw and are typically collected from a subject at the specialized locations. Accessibility of these locations and the venipuncture process in and of itself is a major barrier in compliance and frequency of testing.",
  "cpc": [
    "G01N 35/026",
    "B01L 2200/023",
    "B01L 2200/025",
    "B01L 2200/0673",
    "B01L 2200/0689",
    "B01L 2300/041",
    "B01L 2300/0851",
    "B01L 2300/0893",
    "B01L 2400/0677",
    "B01L 3/0275",
    "B01L 3/0279",
    "B01L 3/5021",
    "B01L 3/502715",
    "B01L 3/50851",
    "B01L 3/50855",
    "B01L 9/527",
    "G01N 2035/00326",
    "G01N 2035/00495",
    "G01N 2035/00881",
    "G01N 2035/0094",
    "G01N 35/00871",
    "G01N 35/0092",
    "G01N 35/10",
    "G01N 35/1065",
    "Y10T 436/2575"
  ],
  "ipc": [
    "B01L 3/02",
    "G01N 35/10",
    "B01L 3/00",
    "G01N 35/00",
    "G01N 35/02"
  ],
  "assignees": [
    "Theranos IP Co LLC"
  ],
  "inventors": [
    "James Wasson",
    "John Kent Frankovich",
    "Elizabeth A. Holmes",
    "Timothy Smith",
    "Michael Chen",
    "Daniel Young"
  ],
  "filing_date": "2014-01-16",
  "publication_date": "2018-07-03",
  "grant_date": "2018-07-03",
  "priority_date": "2011-09-25",
  "application_number": "US-201414157343-A",
  "family_id": "51351479",
  "cited_by_count": 21,
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