Automated system for handling microfluidic devices

{
  "publication_number": "US9207249B2",
  "country": "US",
  "kind": "B2",
  "title": "Automated system for handling microfluidic devices",
  "abstract": "The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.",
  "claims": [
    "1. A cartridge for use with a microfluidic chip processing apparatus, the cartridge comprising: a container having a bottom end defining a bottom opening; and a stack of microfluidic chips disposed in the container above the bottom opening, each of the microfluidic chips having a planar chip portion a continuous interior perimeter and a continuous exterior perimeter; both of the perimeters are perpendicular to the planar chip portion and defined by: a pair of parallel sides, a first end connected between the pair of parallel sides, and a second end connected between the pair of parallel sides opposite the first end, the first end having a first end portion at a first oblique angle to one of the pair of the parallel sides and a second end portion of the at a second oblique angle to the other of the pair of the parallel sides; wherein gravity moves a bottom one of the stack of microfluidic chips to the bottom opening when a preceding one of the stack of microfluidic chips is removed downwardly through the bottom opening by the microfluidic chip processing apparatus, and the container has a cross-section profile complementary to the continuous exterior perimeter of each of the microfluidic chips.",
    "2. The cartridge of claim 1 wherein each of the microfluidic chips includes a mount.",
    "3. The cartridge of claim 1 wherein the second end is parallel to the first end.",
    "4. A microfluidic chip processing system comprising: a microfluidic chip processing apparatus comprising: a housing; a microfluidic chip processing area comprising a fluid control system and a detection system, wherein the fluid control system and the detection system are disposed within the housing, the fluid control system having a fluid driver operable to control fluid motion through one or more channels of a microfluidic chip; a microfluidic chip storage area spaced apart from the microfluidic chip processing area, the microfluidic chip storage area including a receptacle; and a microfluidic chip handling system comprising a conveyor, at least a portion of which extends between the storage area and the processing area, the conveyor having a car operable to engage a side portion of a microfluidic chip disposed in the storage area, the car delivering the microfluidic chip into the housing such that the microfluidic chip is in position to be operably coupled with the fluid control system and the detection system; and a cartridge comprising: a container having a bottom opening; and a stack of microfluidic chips disposed in the container, each of the microfluidic chips having a planar chip portion a continuous interior perimeter and a continuous exterior perimeter; both of the perimeters are perpendicular to the planar chip portion and defined by: a pair of parallel sides, a first end connected between the pair of parallel sides, and a second end connected between the pair of parallel sides opposite the first end, the first end having a first end portion at a first oblique angle to one of the pair of the parallel sides and a second end portion at a second oblique angle to the other of the pair of the parallel sides; wherein gravity moves a bottom one of the stack of microfluidic chips to the bottom opening when a preceding one of the stack of microfluidic chips is removed through the bottom opening by the microfluidic chip processing apparatus, and the container has a cross-section profile complementary to the continuous perimeter of each of the microfluidic chips; wherein the receptacle is sized to receive the cartridge.",
    "5. The system of claim 4 further comprising a reservoir exterior to at least one of the microfluidic chips and in fluid communication with a channel disposed within the at least one of the microfluidic chips, the reservoir being operable to receive material from the at least one of the microfluidic chips.",
    "6. The system of claim 4 wherein the car engages each of the microfluidic chips in series to dispense the microfluidic chips in series.",
    "7. The system of claim 4 wherein each of the microfluidic chips includes a mount.",
    "8. The system of claim 4 further comprising a data output system operable to receive data from the microfluidic chip processing apparatus.",
    "9. The system of claim 8 wherein the data output system is selected from the group consisting of a printer, an ethernet connection, a floppy disk, a CD-ROM drive, a monitor, and a visual display device.",
    "10. The system of claim 4 wherein the microfluidic chip processing apparatus has a footprint of approximately the same size as the footprint of a standard 96-well microtiter plate.",
    "11. The system of claim 4 wherein the second end is parallel to the first end."
  ],
  "description_excerpt": "This invention is generally directed to microfluidic chip devices and an automated apparatus for providing small volume, multifunction lab procedures on microfluidic chips.\n\nThe use of microfluidic technology has been proposed for a number of analytical chemical and biochemical operations. This technology allows one to perform chemical and biochemical reactions, macromolecular separations, and the like, that range from the simple to the relatively complex, in easily automated, high-throughput, low-volume systems. The term “microfluidic” refers to a system or device having micron or submicron scale channels and chambers. In general, microfluidic systems include a microfluidic device, or chip, that has networks of integrated submicron channels in which materials are transported, mixed, separated and detected. Microfluidic systems typically also contain components that provide fluid driving forces to the chip and that detect signals emanating from the chip.\n\nMicrofluidic chips may be fabricated from a number of different materials, including glass or polymeric materials. An example of a commercially available microfluidic chip is shown in FIG. 1. FIG. 1A is a topside view of the chip, and FIG. 1B is a bottom side view of the same chip. That chip, a DNA LabChip® manufactured by Caliper Life Sciences, Inc. of Mountain View Calif., is used with the Agilent 2100 Bioanalyzer system manufactured by Agilent Technologies, Inc. of Palo Alto Calif. The chip in FIG. 1 has two major components: a working part 128 made of glass, and a plastic caddy or mount 127 bonded to the working part.",
  "cpc": [
    "G01N 35/00584",
    "B01L 2300/0819",
    "B01L 3/5027",
    "B01L 3/502715",
    "B01L 9/527",
    "G01N 2021/0346",
    "G01N 2021/058",
    "G01N 21/05",
    "G01N 21/11",
    "G01N 21/13",
    "G01N 35/04",
    "G01N 35/1095"
  ],
  "ipc": [
    "B01L 3/00",
    "G01N 21/05",
    "G01N 21/11",
    "G01N 21/13",
    "G01N 35/00",
    "G01N 35/02",
    "G01N 35/04",
    "B01L 9/00",
    "G01N 35/10"
  ],
  "assignees": [
    "Caliper Life Sciences Inc"
  ],
  "inventors": [
    "Michael Greenstein",
    "Colin B Kennedy",
    "James C Mikkelsen, Jr."
  ],
  "filing_date": "2013-07-29",
  "publication_date": "2015-12-08",
  "grant_date": "2015-12-08",
  "priority_date": "2004-05-21",
  "application_number": "US-201313953572-A",
  "family_id": "34971415",
  "cited_by_count": 8,
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}