Bovine corneal opacity and permeability assay

{
  "id": "MLC-T-ENV-003593",
  "term": "Bovine corneal opacity and permeability assay",
  "field": "Environment",
  "term_source": "Bovine Corneal Opacity and Permeability Assay",
  "definition": "A test method developed in the search for a potential replacement for the Draize rabbit eye test. It uses bovine (cow) eyes that are received shortly after the slaughter of the animal so the cells are still viable. The corneas are excised and treated with a chemical to determine its potential to damage the eye. The BCOP model predicts effects similar to many human corneal responses. The Agency is proposing a pilot interim policy to use BCOP in combination with other non-animal alternative tests such as EpiOcular™ Model and Cytosensor to address the full range of eye irritancy (i.e., Toxicity Categories I through IV) for a limited class of antimicrobial cleaning agents.",
  "abbreviation": "BCOP",
  "subject": "Chemicals, toxics and pesticides",
  "references": [
    "Toxicity Testing and Risk Assessment Glossary"
  ],
  "url": "https://mlchart.com/terminology/environment/bovine-corneal-opacity-and-permeability-assay/"
}