Physiologically Based Pharmacokinetic Model

{
  "id": "MLC-T-ENV-020999",
  "term": "Physiologically Based Pharmacokinetic Model",
  "field": "Environment",
  "definition": "1. A model that estimates the dose to a target tissue or organ by taking into account the rate of absorption into the body, distribution among target organs and tissues, metabolism, and excretion.\n\n2. A mathematical model that estimates the dose to a target tissue or organ by taking into account the rate of absorption into the body, distribution among target organs and tissues, metabolism, and excretion.\n\n3. A computer model that describes what happens to a chemical in the body. This model describes how the chemical gets into the body, where it goes in the body, how it is changed by the body, and how it leaves the body.\n\n4. A model that estimates the dose to a target tissue or organ by taking into account the rate of absorption into the body, distribution among target organs and tissues, metabolism, and excretion. [EPA 2003]\n\n5. A computer model that describes what happens to a chemical in the body. This model describes how the chemical gets into the body, where it goes in the body, how it is changed by the body, and how it leaves the body. [ATSDR 2004]\n\n6. Complex, multi-compartment models that account for an organism’s physiology and the chemical properties of the contaminant.",
  "abbreviation": "PBPK Model",
  "subject": "Science and research",
  "references": [
    "Integrated Risk Information System (IRIS) Glossary; EPA 2003",
    "Toxicity Testing and Risk Assessment Glossary",
    "ATSDR 2004; CDC Agency for Toxic Substances and Disease Registry Glossary",
    "Thesaurus of Terms Used in Microbial Risk Assessment",
    "EPA ExpoBox Terminology"
  ],
  "url": "https://mlchart.com/terminology/environment/physiologically-based-pharmacokinetic-model/"
}