12-lipoxygenase inhibitor VLX-1005

{
  "id": "MLC-T-ONC-009514",
  "term": "12-lipoxygenase inhibitor VLX-1005",
  "field": "Oncology and biomedicine",
  "definition": "A selective small molecule inhibitor of 12-lipoxygenase (12-LOX), with potential anti-platelet and anti-thrombotic activities. Upon intravenous administration, 12-LOX inhibitor VLX-1005 inhibits platelet 12-LOX. This modulates Fc gamma receptor IIa (FcgRIIa; CD32a) signaling, inhibits FcgRIIa-mediated platelet activation and aggregation, and reduces thrombus formation. The activation of the FcgRIIa receptor plays an important role in immune-mediated thrombosis, such as heparin-induced thrombocytopenia (HIT). 12-LOX, an enzyme expressed in platelets, regulates FcgRIIa activity in the platelet.",
  "synonyms": [
    "12-LOX inhibitor VLX-1005"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/12-lipoxygenase-inhibitor-vlx-1005/"
}