4'-iodo-4'-deoxydoxorubicin

{
  "id": "MLC-T-ONC-009541",
  "term": "4'-iodo-4'-deoxydoxorubicin",
  "field": "Oncology and biomedicine",
  "definition": "An iodinated doxorubicin analogue with antiamyloid activity. 4'-Iodo-4'-deoxydoxorubicin (IDOX) binds with high affinity to five types of natural amyloid fibrils including immunoglobulin light chains, amyloid A, transthyretin (methionine-30 variant), beta-protein (Alzheimer), and beta2-microglobulin. This agent may inhibit fibril growth, increasing the solubility of amyloid tissue deposits and facilitating their clearance. IDOX has also been shown to insulin amyloid fibrillogenesis in vitro.",
  "abbreviation": "IDOX",
  "synonyms": [
    "iododoxorubicin",
    "4'-deoxy-4'-iododoxorubicin",
    "iodo-doxorubicin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/4-iodo-4-deoxydoxorubicin/"
}