Dezamizumab

{
  "id": "MLC-T-ONC-013019",
  "term": "Dezamizumab",
  "field": "Oncology and biomedicine",
  "definition": "A fully humanized monoclonal IgG1 anti-serum amyloid P component (SAP) antibody, with potential anti-amyloid activity. Upon intravenous administration, dezamizumab binds to SAP in amyloid deposits, thereby activating compliment and triggering the rapid clearance of amyloid by macrophage-derived multinucleated giant cells. SAP is a universal component of amyloid deposits and contributes to the pathogenesis of amyloidosis.",
  "synonyms": [
    "anti-SAP mAb",
    "anti-SAP monoclonal antibody"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dezamizumab/"
}