4-thio-2-deoxycytidine

{
  "id": "MLC-T-ONC-009545",
  "term": "4-thio-2-deoxycytidine",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable 4-thio modified 2-deoxycytidine analog, with potential antineoplastic activity. Upon administration of 4-thio-2-deoxycytidine (TdCyd), this cytidine analog gets incorporated into DNA during replication and inhibits the activity of DNA methyltransferase 1 (DNMT1), which blocks DNA hypermethylation. This results in DNMT1 depletion, hypomethylation of DNA, and the reactivation of tumor suppressor genes that were silenced by hypermethylation; this results in antitumor activity and an inhibition of tumor cell proliferation.",
  "abbreviation": "TdCyd",
  "synonyms": [
    "4'-thio-2'-deoxycytidine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/4-thio-2-deoxycytidine/"
}