Acridine carboxamide

{
  "id": "MLC-T-ONC-000174",
  "term": "Acridine carboxamide",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor. Also called DACA.",
    "A tricyclic acridine-based (or carboxamide-based) drug with dual topoisomerase inhibitor and potential antineoplastic activities. Acridine carboxamide inhibits both topoisomerases I and II and intercalates into DNA, resulting in DNA damage, the disruption of DNA repair and replication, the inhibition of RNA and protein synthesis, and cell death."
  ],
  "abbreviation": "DACA",
  "synonyms": [
    "DACA"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/acridine-carboxamide/"
}