dacarbazine

{
  "id": "MLC-T-ONC-002264",
  "term": "dacarbazine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat Hodgkin lymphoma that did not get better with other anticancer drugs and melanoma that has spread to other parts of the body. It is also being studied in the treatment of other types of cancer. Dacarbazine damages the cell’s DNA and may kill cancer cells. It is a type of alkylating agent.",
    "A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis."
  ],
  "abbreviation": "DIC",
  "synonyms": [
    "Biocarbazine",
    "Dacarbazina Almirall",
    "Dacarbazina",
    "Dacarbazine - DTIC",
    "Dakarbazin",
    "dimethyl (triazeno) imidazolecarboxamide",
    "dimethyl triazeno imidazol carboxamide",
    "dimethyl triazeno imidazole carboxamide",
    "imidazole carboxamide dimethyltriazeno",
    "imidazole carboxamide",
    "dimethyl-triazeno-imidazole carboxamide",
    "dimethyl-triazeno-imidazole-carboximide"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dacarbazine/"
}