adeno-associated virus encoding anti-CD19/anti-CD3 bispecific diabody VNX-101

{
  "id": "MLC-T-ONC-009657",
  "term": "adeno-associated virus encoding anti-CD19/anti-CD3 bispecific diabody VNX-101",
  "field": "Oncology and biomedicine",
  "definition": "An off-the-shelf preparation of adeno-associated virus (AAV) encoding the anti-CD19/anti-CD3 bispecific diabody GP101, with potential immunostimulating and antineoplastic activities. Upon administration, AAV encoding anti-CD19/anti-CD3 bispecific diabody VNX-101 induces the secretion of GP101 by hepatocytes and other cells into the bloodstream. GP101 binds to both the CD3 antigen on T cells and the CD19 antigen expressed on tumor cells. This results in the cross-linking of T cells and tumor cells, and induces a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.",
  "synonyms": [
    "AAV encoding anti-CD19/anti-CD3 bispecific diabody GP101 VNX-101",
    "AAV encoding anti-CD19/anti-CD3 bispecific diabody VNX-101",
    "AAV encoding anti-CD19/anti-CD3 bispecific T-cell engager VNX-101",
    "AAV.CD3/CD19"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adeno-associated-virus-encoding-anti-cd19-anti-cd3-bispecific-diabody-vnx-101/"
}