adenovirus vector

{
  "id": "MLC-T-ONC-000247",
  "term": "adenovirus vector",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A form of a common virus called adenovirus that is used to deliver genetic material, such as a new gene or a normal copy of a mutated (changed) gene, directly into the nucleus of a cell. Before adenovirus is used in this way, it is changed in the laboratory so that it cannot cause disease in people. When an adenovirus vector is used for gene therapy, a broken, defective, or missing gene inside the body's cells can be repaired or replaced with a healthy version of that gene. Adenovirus vectors may also carry genes that can change abnormal cells, such as cancer cells, back to normal. And they may be used in vaccines to help prevent certain types of viral infections.",
    "One of a number of genetically-engineered adenoviruses designed to insert a gene of interest into a eukaryotic cell where the gene of interest is subsequently expressed. Unlike most other vectors, adenovirus vectors have the ability to infect post-mitotic cells. Thus, these agents are especially useful for gene transfer into neuronal cells."
  ],
  "abbreviation": "ADV",
  "synonyms": [
    "Adenoviral Vector"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adenovirus-vector/"
}