adenovirus serotype 26-expressing HPV18 vaccine JNJ-63682931

{
  "id": "MLC-T-ONC-009695",
  "term": "adenovirus serotype 26-expressing HPV18 vaccine JNJ-63682931",
  "field": "Oncology and biomedicine",
  "definition": "A prime cancer vaccine comprised of a genetically engineered, replication-deficient adenovirus serotype 26 (Ad26) encoding the oncogenic human papillomavirus 18 (HPV18), with potential immunostimulating and antineoplastic activities. Upon intramuscular administration of Ad26-expressing HPV18 vaccine JNJ-63682931, the adenovirus infects and expresses HPV18. The expressed proteins stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing HPV18 antigens, thereby inducing tumor cell lysis. HPV18 infection plays a key role in the development of a variety of cancers.",
  "synonyms": [
    "Ad26-expressing HPV18 vaccine JNJ-63682931",
    "Ad26.HPV18 JNJ-63682931",
    "adenovirus serotype 26-human papillomavirus 18 JNJ-63682931",
    "monovalent HPV18 Ad26-vectored vaccine JNJ-63682931"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adenovirus-serotype-26-expressing-hpv18-vaccine-jnj-63682931/"
}