adenovirus serotype 26-expressing HPV16 vaccine JNJ-63682918

{
  "id": "MLC-T-ONC-009694",
  "term": "adenovirus serotype 26-expressing HPV16 vaccine JNJ-63682918",
  "field": "Oncology and biomedicine",
  "definition": "A prime cancer vaccine comprised of a genetically engineered, replication-deficient adenovirus serotype 26 (Ad26) encoding the oncogenic human papillomavirus 16 (HPV16), with potential immunostimulating and antineoplastic activities. Upon intramuscular administration of Ad26-expressing HPV16 vaccine JNJ-63682918, the adenovirus infects and expresses HPV16. The expressed proteins stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing HPV16 antigens, thereby inducing tumor cell lysis. HPV16 infection plays a key role in the development of a variety of cancers.",
  "synonyms": [
    "Ad26-expressing HPV16 vaccine JNJ-63682918",
    "Ad26.HPV16 JNJ-63682918",
    "adenovirus serotype 26-human papillomavirus 16 JNJ-63682918",
    "monovalent HPV16 Ad26-vectored vaccine JNJ-63682918"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adenovirus-serotype-26-expressing-hpv16-vaccine-jnj-63682918/"
}