alpha-1,3-galactosyltransferase-expressing allogeneic renal cell carcinoma vaccine

{
  "id": "MLC-T-ONC-009978",
  "term": "alpha-1,3-galactosyltransferase-expressing allogeneic renal cell carcinoma vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An allogeneic renal cell cancer (RCC) vaccine composed of cell line-derived RCCs that are genetically engineered to express the murine alpha-1,3-galactosyltransferase (GalT), with potential immunostimulatory and antineoplastic activities. Not naturally occurring in humans, GalT catalyzes the expression of foreign alpha-1,3-galactosyl (alpha-gal) carbohydrate epitopes on the cell membranes of the allogeneic RCCs present in the vaccine. This induces a hyperacute rejection reaction involving pre-existing human anti-alpha-gal antibodies, which bind to the foreign alpha-gal epitopes expressed by the allogeneic RCCs. This results in complement-mediated cytotoxicity (CMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) towards endogenous RCCs with unmodified carbohydrate epitopes.",
  "abbreviation": "HAR",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/alpha-13-galactosyltransferase-expressing-allogeneic-renal-cell-carcinoma/"
}