algenpantucel-L

{
  "id": "MLC-T-ONC-009765",
  "term": "algenpantucel-L",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine comprised of irradiated allogeneic pancreatic cancer cells transfected to express murine alpha-1,3-galactosyltransferase with potential antitumor activity. Vaccination is associated with the expression of murine alpha-1,3-galactosyl (alpha-gal) carbohydrate residues on cell membrane glycoproteins and glycolipids of the vaccine pancreatic cancer cell allograft; murine alpha-gal epitopes, not present on human cells, then induce a hyperacute rejection of the vaccine pancreatic cancer cell allograft. The hyperacute rejection involves the binding of pre-existing human anti-alpha-gal antibodies (which naturally occur against gut flora) to murine alpha-gal epitopes, resulting in the rapid activation of antibody-dependent cell-mediated cytotoxicity (ADCC) towards allograft cells. The host immune system then attacks endogenous pancreatic cancer cells, resulting in ADCC towards endogenous pancreatic cancer cells.",
  "synonyms": [
    "alpha-1,3-galactosyltransferase-expressing allogeneic pancreatic tumor cell Vaccine",
    "alpha (1,3) galactosyltransferase tumor vaccine",
    "hyperacute pancreatic cancer vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/algenpantucel-l/"
}