alpha-galactosylceramide-pulsed autologous dendritic cells

{
  "id": "MLC-T-ONC-009985",
  "term": "alpha-galactosylceramide-pulsed autologous dendritic cells",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine comprised of autologous dendritic cells (DCs) pulsed with the marine sponge glycolipid alpha-galactosylceramide (alpha-GalCer) with potential immunostimulatory and antimetastatic activities. Upon administration, alpha-galactosylceramide-pulsed autologous dendritic cells may result in the activation and proliferation of a subset of endogenous natural killer T ( NKT) cells, B cells, and CD4+ and CD8+ T cells, and the production of interferon-gamma and interleukin-12; these cascade events may result in a T helper-1 cell-biased proinflammatory antitumor immune response. The NKT cell ligand alpha-GalCer was originally isolated from the marine sponge Agelas mauritianusis.",
  "abbreviation": "DC-KRN7000",
  "synonyms": [
    "KRN7000-pulsed autologous dendritic cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/alpha-galactosylceramide-pulsed-autologous-dendritic-cells/"
}