liposomal alpha galactosylceramide

{
  "id": "MLC-T-ONC-014811",
  "term": "liposomal alpha galactosylceramide",
  "field": "Oncology and biomedicine",
  "definition": "A liposomal formulation of alpha galactosylceramide, a synthetic glycolipid isolated from the Okinawan marine sponge (Agelas mauritianus) with potential immunosuppressing activity. Upon administration, alpha galactosylceramide serves as a ligand for CD1d which is expressed on various antigen-presenting cells (APCs) including dendritic cells (DCs), macrophages, and B-cells. This induces the activation of the immunoregulatory invariant natural killer T cells (iNKTs), which induces the expansion of tolerogenic regulatory DCs and, in turn, regulatory T cells (Tregs). Tregs may specifically suppress T-cell responses against host alloantigens, thereby reducing graft rejection while maintaining normal immune cell function. CD1d is a non-polymorphic, major histocompatibility complex (MHC) class I-like antigen-presenting molecule with an antigen-binding groove adapted for the presentation of lipid antigens.",
  "synonyms": [
    "liposomal KRN-7000",
    "liposomal RGI-7000",
    "liposomal alpha-GalCer"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/liposomal-alpha-galactosylceramide/"
}