anti-CD1d/Vdelta2 gamma delta T-cell-engaging bispecific antibody LAVA-051

{
  "id": "MLC-T-ONC-010283",
  "term": "anti-CD1d/Vdelta2 gamma delta T-cell-engaging bispecific antibody LAVA-051",
  "field": "Oncology and biomedicine",
  "definition": "A humanized bispecific gamma delta T-cell engager (TCE) antibody directed against both CD1d and Vdelta2, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD1d gamma delta T-cell-engaging bispecific antibody LAVA-051 binds to both CD1d-expressing tumor cells and Vgamma9Vdelta2 T cells. This activates and redirects the Vgamma9Vdelta2 T cells to CD1d-expressing tumor cells, and the Vgamma9Vdelta2 T cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. The Vgamma9Vdelta2 T cells also activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. In addition, this activates invariant natural killer T cells (iNKTs). The iNKTs secrete large amounts of various cytokines, which may activate the immune system against tumor cells. Additionally, iNKTs directly target and lyse tumor cells. CD1d, an antigen-presenting glycoprotein, plays an important role in the presentation of glycolipid antigens to iNKTs; it is also expressed by various hematologic malignancies.",
  "synonyms": [
    "anti-CD1d/anti-Vdelta2 gamma delta bispecific T-cell engager antibody LAVA-051",
    "CD1d x Vdelta2 gamma delta bsTCE antibody LAVA-051",
    "bsTCE antibody LAVA-051"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd1d-vdelta2-gamma-delta-t-cell-engaging-bispecific-antibody-lava-051/"
}