androgen receptor/glucocorticoid receptor antagonist CB-03-10

{
  "id": "MLC-T-ONC-010080",
  "term": "androgen receptor/glucocorticoid receptor antagonist CB-03-10",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable steroidal cortexolone derivative and antagonist of the androgen receptor (AR) and glucocorticoid receptor (GR), with potential antineoplastic activity. Upon oral administration, AR/GR antagonist CB-03-10 specifically binds to AR and GR, inhibits AR and GR activation, and prevents AR- and GR-mediated signaling. This leads to an induction of both extrinsic and intrinsic apoptotic pathways and inhibits cell growth in AR- and GR-overexpressing tumor cells. AR and GR are overexpressed in certain types of cancer cells and are involved in proliferation, survival and chemoresistance of tumor cells.",
  "synonyms": [
    "AR/GR antagonist CB-03-10"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/androgen-receptor-glucocorticoid-receptor-antagonist-cb-03-10/"
}