anti-CD32B monoclonal antibody BI-1206

{
  "id": "MLC-T-ONC-010335",
  "term": "anti-CD32B monoclonal antibody BI-1206",
  "field": "Oncology and biomedicine",
  "definition": "A fully human monoclonal antibody targeting the Fc gamma receptor IIB (FcgRIIB; CD32B) with potential immunomodulatory and antineoplastic activities. Upon intravenous administration, anti-CD32B monoclonal antibody BI-1206 selectively binds to CD32B, a receptor expressed on the surface of B cells. This prevents CD32B-mediated internalization of anti-CD20 monoclonal antibodies, such as rituximab, which abrogates tumor cell resistance caused by CD32B-mediated monoclonal antibody internalization and degradation of CD32B-expressing B cells. By blocking CD32B, BI-1206 may recover and enhance the activity of rituximab and other anti CD20 monoclonal antibodies. In addition, BI-1206 itself activates the immune system to exert an immune-mediated tumor cell death of B cells. CD32B, an inhibitory member of the FcgammaR family, is implicated in immune cell desensitization and tumor cell resistance.",
  "synonyms": [
    "anti-hFcgammaRIIB mAb BI-1206",
    "anti-hFcgRIIB monoclonal antibody BI-1206"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd32b-monoclonal-antibody-bi-1206/"
}