anti-CD38 scFv/Anti-DOTA scFv fusion protein CD38-SADA

{
  "id": "MLC-T-ONC-010360",
  "term": "anti-CD38 scFv/Anti-DOTA scFv fusion protein CD38-SADA",
  "field": "Oncology and biomedicine",
  "definition": "A fusion protein composed of a single chain variable fragment (scFv) targeting the human cell surface glycoprotein and tumor-associated antigen (TAA) CD38, an scFv targeting the chelating agent 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and a self-assembling and disassembling (SADA) domain that can self-assemble from a monomeric polypeptide into tetrameric protein, that may be used as a pre-targeted radioimmunotherapeutic agent. Upon administration, anti-CD38 scFv/anti-DOTA scFv fusion protein CD38-SADA assembles in tetramers and the anti-CD38 scFv binds to CD38-expressing tumor cells. The unbound CD38-SADA is excreted. Upon administration of a DOTA-based radioactive payload, the anti-DOTA scFv binds to the DOTA moiety of the radioactive payload, and radiation is selectively delivered to tumor cells expressing CD38. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis.",
  "synonyms": [
    "anti-CD38 scFv/anti-DOTA scFv/SADA domain fusion protein CD38-SADA",
    "CD38-SADA"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd38-scfv-anti-dota-scfv-fusion-protein-cd38-sada/"
}